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SMILES: CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC2CNCC2C1

InChI Key: InChIKey=UFYCHKGRLXGWIJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456477   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM456477
PNG
(US10723742, Example 203)
Show SMILES CC(C)(O)Cn1ccc2cc(c(F)c(F)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1CC2CNCC2C1
Show InChI InChI=1S/C32H29F3N4O2/c1-32(2,41)17-38-8-7-19-9-26(28(34)29(35)30(19)38)24-6-5-20(31(40)39-15-22-13-37-14-23(22)16-39)10-25(24)18-3-4-21(12-36)27(33)11-18/h3-11,22-23,37,41H,13-17H2,1-2H3
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PC cid
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US Patent
n/an/a 0.240n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...

US Patent US10723742 (2020)

More data for this
Ligand-Target Pair