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SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)CCN2Cc3ccccc3C2=O)nnc1-c1ccco1

InChI Key: InChIKey=RRLXCWPORMWTTA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456559   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM456559
PNG
(US10736883, Example 2.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCN2Cc3ccccc3C2=O)nnc1-c1ccco1 |(-7.67,1.44,;-6.34,.67,;-5.01,1.44,;-5.01,2.98,;-3.67,3.75,;-2.34,2.98,;-2.34,1.44,;-1.01,.67,;.33,1.44,;-3.67,.67,;-3.67,-.87,;-2.43,-1.77,;-.96,-1.3,;.13,-2.39,;-.64,-3.72,;.9,-3.72,;1.46,-1.62,;2.79,-2.39,;4.13,-1.62,;4.29,-.09,;5.8,.23,;6.57,1.57,;8.11,1.57,;8.88,.23,;8.11,-1.1,;6.57,-1.1,;5.53,-2.24,;5.85,-3.75,;-2.9,-3.24,;-4.44,-3.24,;-4.92,-1.77,;-6.38,-1.3,;-6.86,.17,;-8.4,.17,;-8.88,-1.3,;-7.63,-2.2,)|
Show InChI InChI=1S/C24H23N5O6S/c1-33-18-9-5-10-19(34-2)21(18)29-22(20-11-6-13-35-20)25-26-24(29)27-36(31,32)14-12-28-15-16-7-3-4-8-17(16)23(28)30/h3-11,13H,12,14-15H2,1-2H3,(H,26,27)
PDB

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UniProtKB/SwissProt

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.30E+4n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...

US Patent US10736883 (2020)


BindingDB Entry DOI: 10.7270/Q2JW8HXW
More data for this
Ligand-Target Pair