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SMILES: CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1

InChI Key: InChIKey=TUBKEABUFPHJMX-YOEHRIQHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456560   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456560 (US10736883, Example 3.0) Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1 |r,wD:3.3,2.1,(.32,2.87,;1.66,3.64,;2.99,2.87,;2.99,1.33,;4.33,.56,;1.66,.56,;2.43,-.78,;.89,1.89,;.32,-.21,;.32,-1.75,;1.57,-2.66,;1.09,-4.12,;-.45,-4.12,;-1.35,-5.37,;-2.89,-5.37,;-3.37,-6.83,;-2.12,-7.74,;-2.12,-9.28,;-.87,-6.83,;-.92,-2.66,;-2.39,-2.18,;-3.53,-3.21,;-3.21,-4.72,;-4.35,-5.75,;-4.99,-2.74,;-5.31,-1.23,;-4.17,-.2,;-2.71,-.68,;-1.56,.35,;-1.88,1.86,;4.33,3.64,;5.66,2.87,;6.99,3.64,;6.99,5.18,;8.33,5.95,;5.66,5.95,;4.33,5.18,)| Show InChI InChI=1S/C22H26N8O6S/c1-12-9-23-18(24-10-12)17(33-4)14(3)37(31,32)29-22-28-27-19(15-8-7-13(2)36-15)30(22)16-20(34-5)25-11-26-21(16)35-6/h7-11,14,17H,1-6H3,(H,28,29)/t14-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.310	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair