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SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456568   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM456568
PNG
(US10736883, Example 5.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1 |r,wD:16.17,(-6.73,-3.35,;-5.39,-4.12,;-4.06,-3.35,;-4.06,-1.81,;-2.73,-1.04,;-1.39,-1.81,;-1.39,-3.35,;-.06,-4.12,;1.28,-3.35,;-2.73,-4.12,;-2.73,-5.66,;-1.48,-6.57,;-.02,-6.09,;1.07,-7.18,;1.84,-8.52,;.3,-8.52,;2.41,-6.41,;2.41,-4.87,;3.74,-7.18,;5.07,-6.41,;5.07,-4.87,;6.41,-4.1,;7.74,-4.87,;9.08,-4.1,;7.74,-6.41,;8.89,-7.44,;8.26,-8.85,;6.73,-8.69,;6.41,-7.18,;-1.96,-8.03,;-3.5,-8.03,;-3.97,-6.57,;-5.44,-6.09,;-5.91,-4.63,;-7.45,-4.63,;-7.93,-6.09,;-6.68,-7,)|
PDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.950n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...

US Patent US10736883 (2020)


BindingDB Entry DOI: 10.7270/Q2JW8HXW
More data for this
Ligand-Target Pair