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SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3n(C)cnc23)nnc1-c1ccco1

InChI Key: InChIKey=ZRCUKJBIMKEXTF-AWEZNQCLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456569 (US10736883, Example 6.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3n(C)cnc23)nnc1-c1ccco1 |r,wU:16.17,(-8.36,9.28,;-7.02,8.51,;-5.69,9.28,;-5.69,10.82,;-4.36,11.59,;-3.02,10.82,;-3.02,9.28,;-1.69,8.51,;-.36,9.28,;-4.36,8.51,;-4.36,6.97,;-3.11,6.07,;-1.65,6.54,;-.56,5.45,;.21,4.12,;-1.33,4.12,;.78,6.22,;.78,7.76,;2.11,5.45,;3.44,6.22,;3.44,7.76,;4.78,8.53,;6.11,7.76,;7.44,8.53,;6.11,6.22,;7.26,5.19,;8.76,5.51,;6.63,3.79,;5.1,3.95,;4.78,5.45,;-3.59,4.6,;-5.13,4.6,;-5.6,6.07,;-7.07,6.54,;-7.54,8.01,;-9.08,8.01,;-9.56,6.54,;-8.31,5.64,)| Show InChI InChI=1S/C24H24FN7O5S/c1-14(11-16-20-21(15(25)12-26-16)31(2)13-27-20)38(33,34)30-24-29-28-23(19-9-6-10-37-19)32(24)22-17(35-3)7-5-8-18(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,29,30)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.980	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair