null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1

InChI Key: InChIKey=NZPJFOIIOHCPGE-QRQCRPRQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456573   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456573 (US10736883, Example 10.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:16.17,wD:18.19,(-.07,-1.2,;-1.16,-2.29,;-2.65,-1.9,;-3.05,-.41,;-4.54,-.01,;-5.62,-1.1,;-5.23,-2.59,;-6.31,-3.67,;-7.8,-3.28,;-3.74,-2.98,;-3.34,-4.47,;-1.87,-4.95,;-.54,-4.18,;.79,-4.95,;1.56,-3.61,;.02,-6.28,;2.13,-5.72,;2.13,-7.26,;3.46,-4.95,;3.46,-3.41,;4.79,-5.72,;4.79,-7.26,;6.13,-8.03,;7.51,-7.29,;7.46,-5.72,;6.13,-4.95,;8.84,-8.06,;10.18,-8.83,;-1.87,-6.49,;-3.34,-6.96,;-4.24,-5.72,;-5.73,-5.32,;-6.79,-4.23,;-8.1,-4.55,;-8.1,-6.09,;-9.35,-6.99,;-6.64,-6.56,)| Show InChI InChI=1S/C24H24N6O6S/c1-14-8-11-20(36-14)23-27-28-24(30(23)21-18(34-3)6-5-7-19(21)35-4)29-37(32,33)15(2)22(31)17-10-9-16(12-25)13-26-17/h5-11,13,15,22,31H,1-4H3,(H,28,29)/t15-,22+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.110	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair