null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1

InChI Key: InChIKey=QSYBKUFHWHQWAI-CQSZACIVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456578   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456578 (US10736883, Example 15.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1 |r,wD:16.17,(-.77,6.35,;-1.86,5.26,;-3.34,5.66,;-3.74,7.15,;-5.23,7.55,;-6.32,6.46,;-5.92,4.97,;-7.01,3.88,;-8.5,4.28,;-4.43,4.57,;-4.03,3.09,;-2.57,2.61,;-1.23,3.38,;.1,2.61,;1.43,1.84,;-.67,1.28,;.87,3.94,;.1,5.28,;2.41,3.94,;3.18,5.28,;2.41,6.61,;3.18,7.94,;4.72,7.94,;5.49,9.28,;5.49,6.61,;4.72,5.28,;5.49,3.94,;7.03,3.94,;7.8,2.61,;7.8,5.28,;-2.57,1.07,;-4.03,.59,;-4.94,1.84,;-6.43,2.24,;-7.33,3.48,;-8.8,3.01,;-8.8,1.47,;-7.33,.99,)| Show InChI InChI=1S/C24H25FN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.210	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair