null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2C(N)=O)nnc1-c1ccco1

InChI Key: InChIKey=ZAGIRXVULIDEML-CYBMUJFWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456580 (US10736883, Example 17.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2C(N)=O)nnc1-c1ccco1 |r,wD:16.17,(-6.97,-2.85,;-5.64,-3.62,;-4.3,-2.85,;-4.3,-1.31,;-2.97,-.54,;-1.64,-1.31,;-1.64,-2.85,;-.3,-3.62,;1.03,-2.85,;-2.97,-3.62,;-2.97,-5.3,;-1.72,-6.21,;-.39,-5.44,;.94,-6.21,;.17,-7.54,;1.71,-7.54,;2.28,-5.44,;2.28,-3.9,;3.61,-6.21,;4.94,-5.44,;4.94,-3.9,;6.28,-3.13,;7.61,-3.9,;8.94,-3.13,;7.61,-5.44,;6.28,-6.21,;6.28,-7.75,;4.94,-8.52,;7.61,-8.52,;-2.2,-7.67,;-3.74,-7.67,;-4.22,-6.21,;-5.59,-5.62,;-6.06,-4.16,;-7.6,-4.16,;-8.08,-5.62,;-6.83,-6.53,)| Show InChI InChI=1S/C23H23ClN6O6S/c1-13(10-16-15(21(25)31)11-14(24)12-26-16)37(32,33)29-23-28-27-22(19-8-5-9-36-19)30(23)20-17(34-2)6-4-7-18(20)35-3/h4-9,11-13H,10H2,1-3H3,(H2,25,31)(H,28,29)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair