null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccc(C)o1

InChI Key: InChIKey=PTKWCSFRIKTLBY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456582   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456582 (US10736883, Example 19.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |(1.13,.76,;.04,-.32,;-1.45,.07,;-1.85,1.56,;-3.34,1.96,;-4.43,.87,;-4.03,-.62,;-5.12,-1.7,;-6.6,-1.31,;-2.54,-1.01,;-2.14,-2.5,;-.68,-2.98,;.66,-2.21,;1.99,-2.98,;3.32,-3.75,;1.22,-4.31,;2.76,-1.64,;4.3,-1.64,;5.07,-.31,;6.61,-.31,;7.38,1.02,;6.64,2.4,;5.07,2.36,;4.3,1.02,;7.41,3.74,;8.18,5.07,;-.68,-4.52,;-2.14,-4.99,;-3.05,-3.75,;-4.53,-3.35,;-5.59,-2.26,;-6.9,-2.58,;-6.9,-4.12,;-8.15,-5.02,;-5.44,-4.59,)| Show InChI InChI=1S/C23H22N6O5S/c1-15-7-10-20(34-15)22-26-27-23(29(22)21-18(32-2)5-4-6-19(21)33-3)28-35(30,31)12-11-17-9-8-16(13-24)14-25-17/h4-10,14H,11-12H2,1-3H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair