null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2C#N)nnc1-c1ccco1

InChI Key: InChIKey=RWPQFCLJYLWXEL-AWEZNQCLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456583 (US10736883, Example 20.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2C#N)nnc1-c1ccco1 |r,wU:16.17,(1.08,-3.52,;-.01,-4.6,;-1.5,-4.21,;-1.89,-2.72,;-3.38,-2.32,;-4.47,-3.41,;-4.07,-4.9,;-5.16,-5.99,;-6.65,-5.59,;-2.58,-5.29,;-2.19,-6.78,;-.72,-7.26,;.61,-6.49,;1.95,-7.26,;3.28,-8.03,;1.18,-8.59,;2.72,-5.92,;1.95,-4.59,;4.26,-5.92,;5.03,-4.59,;4.26,-3.26,;5.03,-1.92,;6.57,-1.92,;7.34,-.59,;7.34,-3.26,;6.59,-4.64,;7.36,-5.97,;8.13,-7.31,;-.72,-8.8,;-2.19,-9.27,;-3.09,-8.03,;-4.58,-7.63,;-5.64,-6.54,;-6.95,-6.86,;-6.95,-8.4,;-5.48,-8.88,)| Show InChI InChI=1S/C23H21ClN6O5S/c1-14(10-17-15(12-25)11-16(24)13-26-17)36(31,32)29-23-28-27-22(20-8-5-9-35-20)30(23)21-18(33-2)6-4-7-19(21)34-3/h4-9,11,13-14H,10H2,1-3H3,(H,28,29)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair