null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1

InChI Key: InChIKey=OFCSZFFJFGASCR-ZDUSSCGKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456585 (US10736883, Example 22.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1 |r,wU:16.17,(-7.77,5.88,;-6.43,5.11,;-5.1,5.88,;-5.1,7.42,;-3.76,8.19,;-2.43,7.42,;-2.43,5.88,;-1.1,5.11,;.24,5.88,;-3.76,5.11,;-3.76,3.43,;-2.52,2.52,;-1.03,2.92,;.06,1.83,;-.71,.5,;.83,.5,;1.39,2.6,;1.39,4.14,;2.73,1.83,;4.06,2.6,;5.39,1.83,;6.73,2.6,;6.73,4.14,;8.06,4.91,;5.39,4.91,;4.06,4.14,;-2.99,1.06,;-4.53,1.06,;-5.01,2.52,;-6.38,3.11,;-6.86,4.57,;-8.4,4.57,;-8.87,3.11,;-7.63,2.2,)| Show InChI InChI=1S/C21H21BrN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.310	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair