null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1

InChI Key: InChIKey=QSYBKUFHWHQWAI-AWEZNQCLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456591 (US10736883, Example 28.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1 |r,wU:16.17,(-7.43,-6.02,;-5.95,-6.42,;-4.86,-5.33,;-5.26,-3.84,;-4.17,-2.75,;-2.68,-3.15,;-2.28,-4.64,;-.79,-5.04,;.29,-3.95,;-3.37,-5.73,;-2.86,-7.72,;-1.53,-8.49,;-.2,-7.72,;1.14,-8.49,;.37,-9.83,;2.47,-9.26,;1.91,-7.16,;1.14,-5.82,;3.45,-7.16,;4.22,-5.82,;3.45,-4.49,;4.22,-3.16,;5.76,-3.16,;6.53,-1.82,;6.53,-4.49,;5.76,-5.82,;6.53,-7.16,;8.07,-7.16,;8.84,-8.49,;8.84,-5.82,;-1.85,-10,;-3.38,-10.16,;-4.01,-8.75,;-5.5,-8.35,;-6.19,-6.98,;-7.72,-7.22,;-7.96,-8.74,;-6.58,-9.44,)| Show InChI InChI=1S/C24H25FN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.480	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair