null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccco1

InChI Key: InChIKey=LZQAIHUSQJARSV-HNNXBMFYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456593   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456593 (US10736883, Example 30.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccco1 |r,wU:16.17,(-6.47,-6.16,;-4.99,-6.56,;-3.9,-5.47,;-4.3,-3.99,;-3.21,-2.9,;-1.72,-3.3,;-1.32,-4.78,;.17,-5.18,;1.26,-4.09,;-2.41,-5.87,;-1.9,-7.87,;-.57,-8.64,;.76,-7.87,;2.1,-8.64,;1.33,-9.97,;3.43,-9.41,;2.87,-7.3,;2.1,-5.97,;4.41,-7.3,;5.18,-5.97,;6.72,-5.97,;7.49,-4.63,;6.75,-3.25,;5.18,-3.3,;4.41,-4.63,;7.52,-1.92,;8.29,-.59,;-.89,-10.14,;-2.42,-10.3,;-3.05,-8.9,;-4.53,-8.5,;-5.23,-7.13,;-6.75,-7.37,;-7,-8.89,;-5.62,-9.59,)| Show InChI InChI=1S/C23H22N6O5S/c1-15(12-17-10-9-16(13-24)14-25-17)35(30,31)28-23-27-26-22(20-8-5-11-34-20)29(23)21-18(32-2)6-4-7-19(21)33-3/h4-11,14-15H,12H2,1-3H3,(H,27,28)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair