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SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccco1

InChI Key: InChIKey=OUNWXOXXIQVVRF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456598   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM456598
PNG
(US10736883, Example 35.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccco1 |(-7.4,-1.04,;-5.92,-1.44,;-4.83,-.35,;-5.23,1.13,;-4.14,2.22,;-2.65,1.82,;-2.25,.34,;-.76,-.06,;.33,1.03,;-3.34,-.75,;-2.7,-2.48,;-1.26,-3.03,;.07,-2.26,;1.4,-3.03,;2.74,-3.8,;.63,-4.37,;2.17,-1.7,;3.71,-1.7,;4.48,-.37,;6.02,-.37,;6.79,.97,;6.05,2.35,;4.48,2.3,;3.71,.97,;6.82,3.68,;7.59,5.02,;-1.34,-4.57,;-2.83,-4.97,;-3.67,-3.68,;-5.16,-3.28,;-6,-1.99,;-7.48,-2.39,;-7.56,-3.92,;-6.13,-4.48,)|
Show InChI InChI=1S/C22H20N6O5S/c1-31-17-5-3-6-18(32-2)20(17)28-21(19-7-4-11-33-19)25-26-22(28)27-34(29,30)12-10-16-9-8-15(13-23)14-24-16/h3-9,11,14H,10,12H2,1-2H3,(H,26,27)
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PC cid
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US Patent
n/an/an/an/a 3.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...

US Patent US10736883 (2020)

More data for this
Ligand-Target Pair