null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cn2)nnc1-c1ccco1

InChI Key: InChIKey=ZVAGHKSVXKIBDL-ZDUSSCGKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456600 (US10736883, Example 37.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.29,-7.06,;-4.8,-7.45,;-3.71,-6.36,;-4.11,-4.88,;-3.02,-3.79,;-1.53,-4.19,;-1.14,-5.67,;.35,-6.07,;1.44,-4.98,;-2.23,-6.76,;-1.59,-8.49,;-.15,-9.04,;1.19,-8.27,;2.52,-9.04,;3.85,-9.81,;1.75,-10.38,;3.29,-7.71,;2.52,-6.38,;4.83,-7.71,;5.6,-6.38,;7.14,-6.38,;7.91,-5.04,;7.14,-3.71,;7.91,-2.37,;5.6,-3.71,;4.83,-5.04,;-.23,-10.58,;-1.72,-10.98,;-2.56,-9.69,;-4.04,-9.29,;-4.88,-8,;-6.37,-8.4,;-6.45,-9.93,;-5.01,-10.49,)| Show InChI InChI=1S/C21H21ClN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.60	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair