null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2cnc(C)cn2)nnc1-c1ccc(C)o1

InChI Key: InChIKey=OVRQJXRKKBWMKJ-MRXNPFEDSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456601 (US10736883, Example 38.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2cnc(C)cn2)nnc1-c1ccc(C)o1 |r,wD:16.17,(-6.21,-4.58,;-4.87,-5.35,;-3.54,-4.58,;-3.54,-3.04,;-2.2,-2.27,;-.87,-3.04,;-.87,-4.58,;.46,-5.35,;1.8,-4.58,;-2.2,-5.35,;-2.2,-7.37,;-.96,-8.27,;.53,-7.87,;1.62,-8.96,;.85,-10.3,;2.39,-10.3,;2.95,-8.19,;2.95,-6.65,;4.29,-8.96,;5.62,-8.19,;6.95,-8.96,;8.29,-8.19,;8.29,-6.65,;9.62,-5.88,;6.95,-5.88,;5.62,-6.65,;-1.43,-9.74,;-2.97,-9.74,;-3.45,-8.27,;-4.78,-7.5,;-5.26,-6.04,;-6.8,-6.04,;-7.28,-7.5,;-8.61,-8.27,;-6.03,-8.41,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-12-25-17(13-24-14)11-16(3)35(30,31)28-23-27-26-22(20-10-9-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-10,12-13,16H,11H2,1-5H3,(H,27,28)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair