null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1

InChI Key: InChIKey=NZPJFOIIOHCPGE-IVZQSRNASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456603   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456603 (US10736883, Example 40.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:18.19,16.17,(-7.96,-5.02,;-6.47,-5.42,;-5.38,-4.33,;-5.78,-2.84,;-4.69,-1.75,;-3.2,-2.15,;-2.81,-3.64,;-1.32,-4.04,;-.23,-2.95,;-3.89,-4.73,;-3.26,-6.46,;-1.82,-7.01,;-.48,-6.24,;.85,-7.01,;1.62,-5.67,;.08,-8.34,;2.18,-7.78,;2.18,-9.32,;3.52,-7.01,;3.52,-5.47,;4.85,-7.78,;4.85,-9.32,;6.18,-10.09,;7.57,-9.34,;7.52,-7.78,;6.18,-7.01,;8.9,-10.11,;10.23,-10.88,;-1.9,-8.55,;-3.39,-8.94,;-4.22,-7.65,;-5.71,-7.25,;-6.55,-5.96,;-8.04,-6.36,;-8.12,-7.9,;-9.45,-8.67,;-6.68,-8.45,)| Show InChI InChI=1S/C24H24N6O6S/c1-14-8-11-20(36-14)23-27-28-24(30(23)21-18(34-3)6-5-7-19(21)35-4)29-37(32,33)15(2)22(31)17-10-9-16(12-25)13-26-17/h5-11,13,15,22,31H,1-4H3,(H,28,29)/t15-,22-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair