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SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cn2)nnc1-c1ccco1

InChI Key: InChIKey=YCPDVSQANGEHHV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456604   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM456604
PNG
(US10736883, Example 41.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cn2)nnc1-c1ccco1 |(-7.85,2.26,;-6.51,1.49,;-4.97,1.49,;-4.97,3.03,;-3.64,3.8,;-2.31,3.03,;-2.31,1.49,;-.77,1.49,;0,2.82,;-3.64,.72,;-3.64,-.82,;-2.39,-1.73,;-.91,-1.33,;.18,-2.42,;-.91,-3.51,;.95,-3.75,;1.67,-2.02,;2.76,-3.11,;4.25,-2.71,;5.34,-3.8,;6.82,-3.4,;7.22,-1.91,;8.71,-1.51,;6.13,-.82,;4.65,-1.22,;-2.87,-3.19,;-4.41,-3.19,;-4.88,-1.73,;-6.22,-.96,;-6.69,.51,;-8.23,.51,;-8.71,-.96,;-7.46,-1.86,)|
Show InChI InChI=1S/C21H20FN5O5S/c1-30-16-5-3-6-17(31-2)19(16)27-20(18-7-4-11-32-18)24-25-21(27)26-33(28,29)12-10-15-9-8-14(22)13-23-15/h3-9,11,13H,10,12H2,1-2H3,(H,25,26)
PDB

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PC cid
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US Patent
n/an/an/an/a 12n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...

US Patent US10736883 (2020)


BindingDB Entry DOI: 10.7270/Q2JW8HXW
More data for this
Ligand-Target Pair