null

SMILES: COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccc(C)o1

InChI Key: InChIKey=SYZRTXZDUYXWMK-INIZCTEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456606 (US10736883, Example 43.0) Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.51,-7.22,;-4.03,-7.62,;-2.94,-6.53,;-3.34,-5.05,;-2.25,-3.96,;-.76,-4.36,;-.36,-5.84,;1.13,-6.24,;2.22,-5.15,;-1.45,-6.93,;-.81,-8.66,;.63,-9.21,;1.96,-8.44,;3.3,-9.21,;4.63,-9.98,;2.53,-10.55,;4.07,-7.88,;3.3,-6.54,;5.61,-7.88,;6.38,-6.54,;7.92,-6.54,;8.69,-5.21,;7.92,-3.88,;8.69,-2.54,;6.38,-3.88,;5.61,-5.21,;.55,-10.75,;-.94,-11.15,;-1.78,-9.86,;-3.27,-9.46,;-4.11,-8.17,;-5.59,-8.57,;-5.67,-10.1,;-7.01,-10.87,;-4.24,-10.65,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-9-11-17(25-24-14)13-16(3)35(30,31)28-23-27-26-22(20-12-10-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-12,16H,13H2,1-5H3,(H,27,28)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020)
					More data for this Ligand-Target Pair