null

SMILES: CCc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=YPKTXTVDOMZEBZ-IRXDYDNUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456612   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM456612 (US10736883, Example 53.0) Show SMILES CCc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC |r,wU:8.9,10.11,(10.12,-.96,;10.12,-2.5,;8.79,-3.27,;8.79,-4.81,;7.45,-5.58,;6.12,-4.81,;6.12,-3.27,;7.45,-2.5,;4.78,-5.58,;4.78,-7.12,;3.45,-4.81,;3.45,-3.27,;2.12,-5.58,;.78,-6.35,;2.89,-6.92,;1.35,-4.25,;-.19,-4.25,;-1.1,-5.49,;-2.56,-5.02,;-2.56,-3.48,;-3.81,-2.57,;-3.81,-1.03,;-5.27,-.56,;-6.18,-1.8,;-7.72,-1.8,;-5.27,-3.05,;-1.1,-3,;-.62,-1.54,;-1.65,-.39,;-3.16,-.71,;-4.19,.43,;-1.18,1.07,;.33,1.39,;1.36,.25,;.88,-1.22,;1.91,-2.36,;3.42,-2.03,)| Show InChI InChI=1S/C25H30N6O5S/c1-7-18-13-26-23(27-14-18)16(3)17(4)37(32,33)30-25-29-28-24(21-12-11-15(2)36-21)31(25)22-19(34-5)9-8-10-20(22)35-6/h8-14,16-17H,7H2,1-6H3,(H,29,30)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...				US Patent US10736883 (2020) BindingDB Entry DOI: 10.7270/Q2JW8HXW
					More data for this Ligand-Target Pair