BDBM458405 US10744104, Example 5-14

SMILES: CCOC(=O)C(=O)NC(CC(O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F

InChI Key: InChIKey=PYJYGXPFELOJJG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 458405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM458405 (US10744104, Example 5-14) Show SMILES CCOC(=O)C(=O)NC(CC(O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F Show InChI InChI=1S/C21H21ClFNO6/c1-2-30-21(29)19(26)24-15(11-18(25)20(27)28)9-12-3-5-13(6-4-12)16-10-14(22)7-8-17(16)23/h3-8,10,15,18,25H,2,9,11H2,1H3,(H,24,26)(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...				US Patent US10744104 (2020)
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