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SMILES: CCOC(=O)C(=O)NN(C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F

InChI Key: InChIKey=KQXBNFQQWDSXOU-QGZVFWFLSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 458423   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM458423
PNG
(US10744104, Example 14F)
Show SMILES CCOC(=O)C(=O)NN(C[C@@H](O)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F |r|
Show InChI InChI=1S/C20H20ClFN2O6/c1-2-30-20(29)18(26)23-24(11-17(25)19(27)28)10-12-3-5-13(6-4-12)15-9-14(21)7-8-16(15)22/h3-9,17,25H,2,10-11H2,1H3,(H,23,26)(H,27,28)/t17-/m1/s1
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KEGG

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US Patent
 3.55n/an/an/an/an/an/an/an/a



Theravance Biopharma R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...

US Patent US10744104 (2020)

More data for this
Ligand-Target Pair