BDBM458493 4-((benzyloxy)amino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine::US10745383, Example 8

SMILES: FC(F)(F)c1cccc(n1)-c1nc(NOCc2ccccc2)nc(Nc2ccnc(c2)C(F)(F)F)n1

InChI Key: InChIKey=DZDDIUOGNNJMLO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 458493   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human))	BDBM458493 (4-((benzyloxy)amino)-6-(6-(trifluoromethyl)pyridin...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(NOCc2ccccc2)nc(Nc2ccnc(c2)C(F)(F)F)n1 Show InChI InChI=1S/C22H15F6N7O/c23-21(24,25)16-8-4-7-15(31-16)18-32-19(30-14-9-10-29-17(11-14)22(26,27)28)34-20(33-18)35-36-12-13-5-2-1-3-6-13/h1-11H,12H2,(H2,29,30,32,33,34,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	239	n/a	n/a	n/a	n/a	n/a	n/a
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent					Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre...				US Patent US10745383 (2020)
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