BindingDB logo
myBDB logout

BDBM458965 (4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(6-methoxypyridin-2-yl)methanone::US10759794, Example 3

SMILES: COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=CROTXORBJIXBSO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458965   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM458965
PNG
((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...


US Patent US10759794 (2020)

More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM458965
PNG
((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...


US Patent US10759794 (2020)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM458965
PNG
((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 139n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...


US Patent US10759794 (2020)

More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM458965
PNG
((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27.9n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...


US Patent US10759794 (2020)

More data for this
Ligand-Target Pair