BDBM458965 (4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(6-methoxypyridin-2-yl)methanone::US10759794, Example 3
SMILES: COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
InChI Key: InChIKey=CROTXORBJIXBSO-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium channel protein TASK-1 (Homo sapiens (Human)) | BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 9 (Homo sapiens (Human)) | BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel protein TASK-1 (Homo sapiens (Human)) | BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 9 (Homo sapiens (Human)) | BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27.9 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair |