null
SMILES: FC(F)(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1
InChI Key: InChIKey=SIFMANNOUHDCIV-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium channel subfamily K member 9 (Homo sapiens (Human)) | BDBM459029 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel subfamily K member 3 (Homo sapiens (Human)) | BDBM459029 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com... | US Patent US10759794 (2020) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |