null

SMILES: CS(=O)(=O)N1CC[C@@H](Nc2ncc(Cl)c(n2)-c2cc(F)c3ncn(C4CCOC4)c3c2)[C@H](O)C1

InChI Key: InChIKey=LERGEXSFRXRSFX-FMRBYIFOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 462097   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM462097 (US10766884, Example A14 | US11220494, Example A14) Show SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc(Cl)c(n2)-c2cc(F)c3ncn(C4CCOC4)c3c2)[C@H](O)C1 |r| Show InChI InChI=1S/C21H24ClFN6O4S/c1-34(31,32)28-4-2-16(18(30)9-28)26-21-24-8-14(22)19(27-21)12-6-15(23)20-17(7-12)29(11-25-20)13-3-5-33-10-13/h6-8,11,13,16,18,30H,2-5,9-10H2,1H3,(H,24,26,27)/t13?,16-,18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...				US Patent US10766884 (2020) BindingDB Entry DOI: 10.7270/Q23F4SQG
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM462097 (US10766884, Example A14 | US11220494, Example A14) Show SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc(Cl)c(n2)-c2cc(F)c3ncn(C4CCOC4)c3c2)[C@H](O)C1 |r| Show InChI InChI=1S/C21H24ClFN6O4S/c1-34(31,32)28-4-2-16(18(30)9-28)26-21-24-8-14(22)19(27-21)12-6-15(23)20-17(7-12)29(11-25-20)13-3-5-33-10-13/h6-8,11,13,16,18,30H,2-5,9-10H2,1H3,(H,24,26,27)/t13?,16-,18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XG9V9M
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM462097 (US10766884, Example A14 | US11220494, Example A14) Show SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc(Cl)c(n2)-c2cc(F)c3ncn(C4CCOC4)c3c2)[C@H](O)C1 |r| Show InChI InChI=1S/C21H24ClFN6O4S/c1-34(31,32)28-4-2-16(18(30)9-28)26-21-24-8-14(22)19(27-21)12-6-15(23)20-17(7-12)29(11-25-20)13-3-5-33-10-13/h6-8,11,13,16,18,30H,2-5,9-10H2,1H3,(H,24,26,27)/t13?,16-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XG9V9M
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human))	BDBM462097 (US10766884, Example A14 | US11220494, Example A14) Show SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc(Cl)c(n2)-c2cc(F)c3ncn(C4CCOC4)c3c2)[C@H](O)C1 |r| Show InChI InChI=1S/C21H24ClFN6O4S/c1-34(31,32)28-4-2-16(18(30)9-28)26-21-24-8-14(22)19(27-21)12-6-15(23)20-17(7-12)29(11-25-20)13-3-5-33-10-13/h6-8,11,13,16,18,30H,2-5,9-10H2,1H3,(H,24,26,27)/t13?,16-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...				US Patent US10766884 (2020) BindingDB Entry DOI: 10.7270/Q23F4SQG
					More data for this Ligand-Target Pair