Found 4 hits for monomerid = 462199 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462199
(US10766884, Example F17 | US11220494, Example F17)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)C(=O)CO)ncc1F |r| Show InChI InChI=1S/C22H26F2N6O3/c1-11(2)30-12(3)26-21-14(23)6-13(7-17(21)30)20-15(24)8-25-22(28-20)27-16-4-5-29(9-18(16)32)19(33)10-31/h6-8,11,16,18,31-32H,4-5,9-10H2,1-3H3,(H,25,27,28)/t16-,18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ... |
US Patent US10766884 (2020)
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462199
(US10766884, Example F17 | US11220494, Example F17)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)C(=O)CO)ncc1F |r| Show InChI InChI=1S/C22H26F2N6O3/c1-11(2)30-12(3)26-21-14(23)6-13(7-17(21)30)20-15(24)8-25-22(28-20)27-16-4-5-29(9-18(16)32)19(33)10-31/h6-8,11,16,18,31-32H,4-5,9-10H2,1-3H3,(H,25,27,28)/t16-,18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462199
(US10766884, Example F17 | US11220494, Example F17)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)C(=O)CO)ncc1F |r| Show InChI InChI=1S/C22H26F2N6O3/c1-11(2)30-12(3)26-21-14(23)6-13(7-17(21)30)20-15(24)8-25-22(28-20)27-16-4-5-29(9-18(16)32)19(33)10-31/h6-8,11,16,18,31-32H,4-5,9-10H2,1-3H3,(H,25,27,28)/t16-,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462199
(US10766884, Example F17 | US11220494, Example F17)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCN(C[C@H]2O)C(=O)CO)ncc1F |r| Show InChI InChI=1S/C22H26F2N6O3/c1-11(2)30-12(3)26-21-14(23)6-13(7-17(21)30)20-15(24)8-25-22(28-20)27-16-4-5-29(9-18(16)32)19(33)10-31/h6-8,11,16,18,31-32H,4-5,9-10H2,1-3H3,(H,25,27,28)/t16-,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo... |
US Patent US10766884 (2020)
|
More data for this
Ligand-Target Pair | |
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