Found 4 hits for monomerid = 462226 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462226
(US10766884, Example H10 | US11220494, Example H10)Show SMILES CC(C)NCc1nc2c(F)cc(cc2n1C(C)C)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C24H33ClFN7O3S/c1-13(2)27-11-21-30-23-17(26)8-15(9-19(23)33(21)14(3)4)22-16(25)10-28-24(31-22)29-18-6-7-32(12-20(18)34)37(5,35)36/h8-10,13-14,18,20,27,34H,6-7,11-12H2,1-5H3,(H,28,29,31)/t18-,20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ... |
US Patent US10766884 (2020)
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)) | BDBM462226
(US10766884, Example H10 | US11220494, Example H10)Show SMILES CC(C)NCc1nc2c(F)cc(cc2n1C(C)C)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C24H33ClFN7O3S/c1-13(2)27-11-21-30-23-17(26)8-15(9-19(23)33(21)14(3)4)22-16(25)10-28-24(31-22)29-18-6-7-32(12-20(18)34)37(5,35)36/h8-10,13-14,18,20,27,34H,6-7,11-12H2,1-5H3,(H,28,29,31)/t18-,20-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462226
(US10766884, Example H10 | US11220494, Example H10)Show SMILES CC(C)NCc1nc2c(F)cc(cc2n1C(C)C)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C24H33ClFN7O3S/c1-13(2)27-11-21-30-23-17(26)8-15(9-19(23)33(21)14(3)4)22-16(25)10-28-24(31-22)29-18-6-7-32(12-20(18)34)37(5,35)36/h8-10,13-14,18,20,27,34H,6-7,11-12H2,1-5H3,(H,28,29,31)/t18-,20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 16.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human)) | BDBM462226
(US10766884, Example H10 | US11220494, Example H10)Show SMILES CC(C)NCc1nc2c(F)cc(cc2n1C(C)C)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C24H33ClFN7O3S/c1-13(2)27-11-21-30-23-17(26)8-15(9-19(23)33(21)14(3)4)22-16(25)10-28-24(31-22)29-18-6-7-32(12-20(18)34)37(5,35)36/h8-10,13-14,18,20,27,34H,6-7,11-12H2,1-5H3,(H,28,29,31)/t18-,20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 16.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo... |
US Patent US10766884 (2020)
|
More data for this Ligand-Target Pair | |