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SMILES: OC1(Cn2cnc3n(c(Cl)cc3c2=O)-c2ccc3OCOc3c2)CCN(CC1)C(=O)c1cnc(o1)C1CC1

InChI Key: InChIKey=FCIKZPYSLYMVPO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 462624   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))		BDBM462624
PNG
(US10766903, Example 236)
Show SMILES OC1(Cn2cnc3n(c(Cl)cc3c2=O)-c2ccc3OCOc3c2)CCN(CC1)C(=O)c1cnc(o1)C1CC1
Show InChI InChI=1S/C26H24ClN5O6/c27-21-10-17-22(32(21)16-3-4-18-19(9-16)37-14-36-18)29-13-31(24(17)33)12-26(35)5-7-30(8-6-26)25(34)20-11-28-23(38-20)15-1-2-15/h3-4,9-11,13,15,35H,1-2,5-8,12,14H2
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US Patent
n/an/a<250n/an/an/an/an/an/a



ALMAC DISCOVERY LIMITED

US Patent


Assay Description
USP7 activity was monitored in a fluorescence polarisation (FP) homogeneous assay using the isopeptide ubiquitin-Lys-TAMRA substrate (U-558, Boston B...

US Patent US10766903 (2020)

More data for this
Ligand-Target Pair