BindingDB logo
myBDB logout

null

SMILES: CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1

InChI Key: InChIKey=CRPFIYXBQORQJX-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466584   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
10n/an/an/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US11014905 (2021)


BindingDB Entry DOI: 10.7270/Q2C53PZQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
37n/an/an/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US11014905 (2021)


BindingDB Entry DOI: 10.7270/Q2C53PZQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
>1.00E+4n/an/an/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US11014905 (2021)


BindingDB Entry DOI: 10.7270/Q2C53PZQ
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 42n/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 86n/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM466584
PNG
(N-(2-{4-[6-(Dimethylamino)pyridin-2-yl]piperidin-1...)
Show SMILES CN(C)c1cccc(n1)C1CCN(CCNC(=O)C2CCOCC2)CC1
Show InChI InChI=1S/C20H32N4O2/c1-23(2)19-5-3-4-18(22-19)16-6-11-24(12-7-16)13-10-21-20(25)17-8-14-26-15-9-17/h3-5,16-17H,6-15H2,1-2H3,(H,21,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...


US Patent US10800755 (2020)


BindingDB Entry DOI: 10.7270/Q2TM7F5J
More data for this
Ligand-Target Pair