null

SMILES: NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\C(F)F

InChI Key: InChIKey=RBODKSYPSRHVMB-XAVKZTDYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM470497 (5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...) Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\C(F)F |r| Show InChI InChI=1S/C24H23ClF2N6O3/c25-15-5-9-19(30-12-15)36-17-6-3-14(4-7-17)22-21(24(29)35)23(28)33(31-22)16-2-1-11-32(13-16)20(34)10-8-18(26)27/h3-10,12,16,18H,1-2,11,13,28H2,(H2,29,35)/b10-8+/t16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description EGFR: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide subs...				US Patent US10815213 (2020) BindingDB Entry DOI: 10.7270/Q2W95D87
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM470497 (5-amino-3-{4-[(5-chloropyridin-2-yl)oxy]phenyl}-1-...) Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)[C@@H]1CCCN(C1)C(=O)\C=C\C(F)F |r| Show InChI InChI=1S/C24H23ClF2N6O3/c25-15-5-9-19(30-12-15)36-17-6-3-14(4-7-17)22-21(24(29)35)23(28)33(31-22)16-2-1-11-32(13-16)20(34)10-8-18(26)27/h3-10,12,16,18H,1-2,11,13,28H2,(H2,29,35)/b10-8+/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...				US Patent US10815213 (2020) BindingDB Entry DOI: 10.7270/Q2W95D87
					More data for this Ligand-Target Pair