BDBM470533 N-(2-chloro-6-fluoro-3-methoxyphenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide::US10815215, Example 193

SMILES: CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)ccc(OC)c2Cl)c1=O

InChI Key: InChIKey=UIPCXTGICSQKQG-JTQLQIEISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470533 (N-(2-chloro-6-fluoro-3-methoxyphenyl)-4-[4-ethyl-3...) Show SMILES CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)ccc(OC)c2Cl)c1=O |r| Show InChI InChI=1S/C22H20ClF5N4O5/c1-4-31-17(9-33)30-32(21(31)35)14-8-16(37-10(2)22(26,27)28)11(7-13(14)25)20(34)29-19-12(24)5-6-15(36-3)18(19)23/h5-8,10,33H,4,9H2,1-3H3,(H,29,34)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470533 (N-(2-chloro-6-fluoro-3-methoxyphenyl)-4-[4-ethyl-3...) Show SMILES CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)ccc(OC)c2Cl)c1=O |r| Show InChI InChI=1S/C22H20ClF5N4O5/c1-4-31-17(9-33)30-32(21(31)35)14-8-16(37-10(2)22(26,27)28)11(7-13(14)25)20(34)29-19-12(24)5-6-15(36-3)18(19)23/h5-8,10,33H,4,9H2,1-3H3,(H,29,34)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020)
					More data for this Ligand-Target Pair