null

SMILES: CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C

InChI Key: InChIKey=GEZPFNXFSSKERU-KENLBAMCSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 472924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10836763 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10844057 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10836763 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10844057 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10836763 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10844057 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10836763 (2020)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM472924 (US10836763, Example 6 | US10844057, Example 6) Show SMILES CCc1cc(O)ccc1-c1ccc2c(n[nH]c2c1)-c1nc2C[C@H](N(Cc2[nH]1)C(C)C)C(=O)N1CC[C@@H](C1)N(C)C |r| Show InChI InChI=1S/C31H37N7O2/c1-6-19-13-22(39)8-10-23(19)20-7-9-24-25(14-20)34-35-29(24)30-32-26-15-28(38(18(2)3)17-27(26)33-30)31(40)37-12-11-21(16-37)36(4)5/h7-10,13-14,18,21,28,39H,6,11-12,15-17H2,1-5H3/b30-29-/t21-,28-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma R&D IP, LLC US Patent					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				US Patent US10844057 (2020)
					More data for this Ligand-Target Pair