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SMILES: C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(NC(C)=O)nc1C

InChI Key: InChIKey=FJHUMWRTKPAXRM-LBPRGKRZSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 474008   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM474008
PNG
(N-(5-{2-[(1S)-1-Cyclopropylethyl]-7-(oxetan-3-ylsu...)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC1COC1)-c1sc(NC(C)=O)nc1C |r|
Show InChI InChI=1S/C22H26N4O5S2/c1-11-20(32-22(23-11)24-13(3)27)15-6-16-8-26(12(2)14-4-5-14)21(28)19(16)18(7-15)33(29,30)25-17-9-31-10-17/h6-7,12,14,17,25H,4-5,8-10H2,1-3H3,(H,23,24,27)/t12-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.631n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...

US Patent US10858355 (2020)

More data for this
Ligand-Target Pair