Found 4 hits for monomerid = 475610 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this Ligand-Target Pair | |