Found 8 hits for monomerid = 475619 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |