Found 8 hits for monomerid = 475635 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM475635
![PNG](/data/jpeg/tenK47/BindingDB_475635.png) (US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
|
More data for this Ligand-Target Pair | |