Found 4 hits for monomerid = 475643 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475643
![PNG](/data/jpeg/tenK47/BindingDB_475643.png) (US10851102, Example 36 | US11339160, Ex No. 36)Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475643
![PNG](/data/jpeg/tenK47/BindingDB_475643.png) (US10851102, Example 36 | US11339160, Ex No. 36)Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475643
![PNG](/data/jpeg/tenK47/BindingDB_475643.png) (US10851102, Example 36 | US11339160, Ex No. 36)Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475643
![PNG](/data/jpeg/tenK47/BindingDB_475643.png) (US10851102, Example 36 | US11339160, Ex No. 36)Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this Ligand-Target Pair | |