Found 4 hits for monomerid = 475654 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
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