Found 4 hits for monomerid = 476819 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476819
(US10870660, Compound III-441 | US11345716, Compoun...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3sc(OCC(C)(F)F)nc3C2)CC1 |r,wU:16.18,wD:13.14,(12.42,-2.23,;11.65,-.9,;10.12,-.74,;9.8,.77,;8.47,1.54,;8.47,3.08,;9.8,3.85,;11.13,3.08,;11.13,1.54,;12.28,.51,;7.13,.77,;7.13,-.77,;5.8,1.54,;4.47,.77,;3.13,1.54,;1.8,.77,;1.8,-.77,;.47,-1.54,;-.87,-.77,;-2.2,-1.54,;-2.2,-3.08,;-3.54,-3.85,;-4.87,-3.08,;-6.33,-3.56,;-7.24,-2.31,;-8.78,-2.31,;-9.55,-.98,;-11.09,-.98,;-11.86,.36,;-12.42,-1.75,;-11.09,-2.52,;-6.33,-1.06,;-4.87,-1.54,;-3.54,-.77,;3.13,-1.54,;4.47,-.77,)| Show InChI InChI=1S/C26H33F2N5O2S/c1-26(27,28)16-35-25-30-22-15-33(13-11-23(22)36-25)12-10-17-6-8-18(9-7-17)29-24(34)19-4-3-5-21-20(19)14-32(2)31-21/h3-5,14,17-18H,6-13,15-16H2,1-2H3,(H,29,34)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description
225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
|
More data for this
Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476819
(US10870660, Compound III-441 | US11345716, Compoun...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3sc(OCC(C)(F)F)nc3C2)CC1 |r,wU:16.18,wD:13.14,(12.42,-2.23,;11.65,-.9,;10.12,-.74,;9.8,.77,;8.47,1.54,;8.47,3.08,;9.8,3.85,;11.13,3.08,;11.13,1.54,;12.28,.51,;7.13,.77,;7.13,-.77,;5.8,1.54,;4.47,.77,;3.13,1.54,;1.8,.77,;1.8,-.77,;.47,-1.54,;-.87,-.77,;-2.2,-1.54,;-2.2,-3.08,;-3.54,-3.85,;-4.87,-3.08,;-6.33,-3.56,;-7.24,-2.31,;-8.78,-2.31,;-9.55,-.98,;-11.09,-.98,;-11.86,.36,;-12.42,-1.75,;-11.09,-2.52,;-6.33,-1.06,;-4.87,-1.54,;-3.54,-.77,;3.13,-1.54,;4.47,-.77,)| Show InChI InChI=1S/C26H33F2N5O2S/c1-26(27,28)16-35-25-30-22-15-33(13-11-23(22)36-25)12-10-17-6-8-18(9-7-17)29-24(34)19-4-3-5-21-20(19)14-32(2)31-21/h3-5,14,17-18H,6-13,15-16H2,1-2H3,(H,29,34)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476819
(US10870660, Compound III-441 | US11345716, Compoun...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3sc(OCC(C)(F)F)nc3C2)CC1 |r,wU:16.18,wD:13.14,(12.42,-2.23,;11.65,-.9,;10.12,-.74,;9.8,.77,;8.47,1.54,;8.47,3.08,;9.8,3.85,;11.13,3.08,;11.13,1.54,;12.28,.51,;7.13,.77,;7.13,-.77,;5.8,1.54,;4.47,.77,;3.13,1.54,;1.8,.77,;1.8,-.77,;.47,-1.54,;-.87,-.77,;-2.2,-1.54,;-2.2,-3.08,;-3.54,-3.85,;-4.87,-3.08,;-6.33,-3.56,;-7.24,-2.31,;-8.78,-2.31,;-9.55,-.98,;-11.09,-.98,;-11.86,.36,;-12.42,-1.75,;-11.09,-2.52,;-6.33,-1.06,;-4.87,-1.54,;-3.54,-.77,;3.13,-1.54,;4.47,-.77,)| Show InChI InChI=1S/C26H33F2N5O2S/c1-26(27,28)16-35-25-30-22-15-33(13-11-23(22)36-25)12-10-17-6-8-18(9-7-17)29-24(34)19-4-3-5-21-20(19)14-32(2)31-21/h3-5,14,17-18H,6-13,15-16H2,1-2H3,(H,29,34)/t17-,18- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476819
(US10870660, Compound III-441 | US11345716, Compoun...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3sc(OCC(C)(F)F)nc3C2)CC1 |r,wU:16.18,wD:13.14,(12.42,-2.23,;11.65,-.9,;10.12,-.74,;9.8,.77,;8.47,1.54,;8.47,3.08,;9.8,3.85,;11.13,3.08,;11.13,1.54,;12.28,.51,;7.13,.77,;7.13,-.77,;5.8,1.54,;4.47,.77,;3.13,1.54,;1.8,.77,;1.8,-.77,;.47,-1.54,;-.87,-.77,;-2.2,-1.54,;-2.2,-3.08,;-3.54,-3.85,;-4.87,-3.08,;-6.33,-3.56,;-7.24,-2.31,;-8.78,-2.31,;-9.55,-.98,;-11.09,-.98,;-11.86,.36,;-12.42,-1.75,;-11.09,-2.52,;-6.33,-1.06,;-4.87,-1.54,;-3.54,-.77,;3.13,-1.54,;4.47,-.77,)| Show InChI InChI=1S/C26H33F2N5O2S/c1-26(27,28)16-35-25-30-22-15-33(13-11-23(22)36-25)12-10-17-6-8-18(9-7-17)29-24(34)19-4-3-5-21-20(19)14-32(2)31-21/h3-5,14,17-18H,6-13,15-16H2,1-2H3,(H,29,34)/t17-,18- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description
225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
|
More data for this
Ligand-Target Pair | |
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