Found 6 hits for monomerid = 476863 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 0.0220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25T3PQ8 |
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 0.0590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25T3PQ8 |
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description 225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
BindingDB Entry DOI: 10.7270/Q2M61PBD |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25T3PQ8 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25T3PQ8 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476863
![PNG](/data/jpeg/tenK47/BindingDB_476863.png) (US10870660, Compound II-046 | US11345716, Compound...)Show SMILES Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-11.23,-5.1,;-12.57,-4.33,;-12.57,-2.79,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)| Show InChI InChI=1S/C26H32F3N5O2S/c1-33-15-20-19(3-2-4-21(20)32-33)24(35)30-18-7-5-17(6-8-18)9-12-34-13-10-22-23(11-14-34)37-25(31-22)36-16-26(27,28)29/h2-4,15,17-18H,5-14,16H2,1H3,(H,30,35)/t17-,18- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description 225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
BindingDB Entry DOI: 10.7270/Q2M61PBD |
More data for this Ligand-Target Pair | |