Found 4 hits for monomerid = 476882 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476882
![PNG](/data/jpeg/tenK47/BindingDB_476882.png) (US10870660, Compound I-071 | US11345716, Compound ...)Show SMILES CC(F)(F)COc1nc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4ncccc34)CCc2s1 |r,wU:13.12,wD:16.19,(-11.88,.36,;-11.11,-.98,;-11.11,-2.52,;-12.45,-1.75,;-9.57,-.98,;-8.8,-2.31,;-7.26,-2.31,;-6.36,-1.06,;-4.89,-1.54,;-3.56,-.77,;-2.22,-1.54,;-.89,-.77,;.44,-1.54,;1.78,-.77,;1.78,.77,;3.11,1.54,;4.44,.77,;4.44,-.77,;3.11,-1.54,;5.78,1.54,;7.11,.77,;7.11,-.77,;8.44,1.54,;8.44,3.08,;9.78,3.85,;11.11,3.08,;11.11,1.54,;12.45,.77,;12.45,-.77,;11.11,-1.54,;9.78,-.77,;9.78,.77,;-2.22,-3.08,;-3.56,-3.85,;-4.89,-3.08,;-6.36,-3.56,)| Show InChI InChI=1S/C27H32F2N4O2S/c1-27(28,29)17-35-26-32-23-16-33(15-12-24(23)36-26)14-11-18-7-9-19(10-8-18)31-25(34)21-4-2-6-22-20(21)5-3-13-30-22/h2-6,13,18-19H,7-12,14-17H2,1H3,(H,31,34)/t18-,19- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description 225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
|
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM476882
![PNG](/data/jpeg/tenK47/BindingDB_476882.png) (US10870660, Compound I-071 | US11345716, Compound ...)Show SMILES CC(F)(F)COc1nc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4ncccc34)CCc2s1 |r,wU:13.12,wD:16.19,(-11.88,.36,;-11.11,-.98,;-11.11,-2.52,;-12.45,-1.75,;-9.57,-.98,;-8.8,-2.31,;-7.26,-2.31,;-6.36,-1.06,;-4.89,-1.54,;-3.56,-.77,;-2.22,-1.54,;-.89,-.77,;.44,-1.54,;1.78,-.77,;1.78,.77,;3.11,1.54,;4.44,.77,;4.44,-.77,;3.11,-1.54,;5.78,1.54,;7.11,.77,;7.11,-.77,;8.44,1.54,;8.44,3.08,;9.78,3.85,;11.11,3.08,;11.11,1.54,;12.45,.77,;12.45,-.77,;11.11,-1.54,;9.78,-.77,;9.78,.77,;-2.22,-3.08,;-3.56,-3.85,;-4.89,-3.08,;-6.36,-3.56,)| Show InChI InChI=1S/C27H32F2N4O2S/c1-27(28,29)17-35-26-32-23-16-33(15-12-24(23)36-26)14-11-18-7-9-19(10-8-18)31-25(34)21-4-2-6-22-20(21)5-3-13-30-22/h2-6,13,18-19H,7-12,14-17H2,1H3,(H,31,34)/t18-,19- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476882
![PNG](/data/jpeg/tenK47/BindingDB_476882.png) (US10870660, Compound I-071 | US11345716, Compound ...)Show SMILES CC(F)(F)COc1nc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4ncccc34)CCc2s1 |r,wU:13.12,wD:16.19,(-11.88,.36,;-11.11,-.98,;-11.11,-2.52,;-12.45,-1.75,;-9.57,-.98,;-8.8,-2.31,;-7.26,-2.31,;-6.36,-1.06,;-4.89,-1.54,;-3.56,-.77,;-2.22,-1.54,;-.89,-.77,;.44,-1.54,;1.78,-.77,;1.78,.77,;3.11,1.54,;4.44,.77,;4.44,-.77,;3.11,-1.54,;5.78,1.54,;7.11,.77,;7.11,-.77,;8.44,1.54,;8.44,3.08,;9.78,3.85,;11.11,3.08,;11.11,1.54,;12.45,.77,;12.45,-.77,;11.11,-1.54,;9.78,-.77,;9.78,.77,;-2.22,-3.08,;-3.56,-3.85,;-4.89,-3.08,;-6.36,-3.56,)| Show InChI InChI=1S/C27H32F2N4O2S/c1-27(28,29)17-35-26-32-23-16-33(15-12-24(23)36-26)14-11-18-7-9-19(10-8-18)31-25(34)21-4-2-6-22-20(21)5-3-13-30-22/h2-6,13,18-19H,7-12,14-17H2,1H3,(H,31,34)/t18-,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM476882
![PNG](/data/jpeg/tenK47/BindingDB_476882.png) (US10870660, Compound I-071 | US11345716, Compound ...)Show SMILES CC(F)(F)COc1nc2CN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc4ncccc34)CCc2s1 |r,wU:13.12,wD:16.19,(-11.88,.36,;-11.11,-.98,;-11.11,-2.52,;-12.45,-1.75,;-9.57,-.98,;-8.8,-2.31,;-7.26,-2.31,;-6.36,-1.06,;-4.89,-1.54,;-3.56,-.77,;-2.22,-1.54,;-.89,-.77,;.44,-1.54,;1.78,-.77,;1.78,.77,;3.11,1.54,;4.44,.77,;4.44,-.77,;3.11,-1.54,;5.78,1.54,;7.11,.77,;7.11,-.77,;8.44,1.54,;8.44,3.08,;9.78,3.85,;11.11,3.08,;11.11,1.54,;12.45,.77,;12.45,-.77,;11.11,-1.54,;9.78,-.77,;9.78,.77,;-2.22,-3.08,;-3.56,-3.85,;-4.89,-3.08,;-6.36,-3.56,)| Show InChI InChI=1S/C27H32F2N4O2S/c1-27(28,29)17-35-26-32-23-16-33(15-12-24(23)36-26)14-11-18-7-9-19(10-8-18)31-25(34)21-4-2-6-22-20(21)5-3-13-30-22/h2-6,13,18-19H,7-12,14-17H2,1H3,(H,31,34)/t18-,19- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SHIONOGI & CO., LTD.
US Patent
| Assay Description 225 nL of the solutions of the non-specific ligand or the compounds of the present invention at each concentration (in case of vehicle, final concent... |
US Patent US10870660 (2020)
|
More data for this Ligand-Target Pair | |