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SMILES: C[C@@H]1C[C@H](N)CN1c1nc2cc(ccc2o1)-c1cccc(COc2cc(OCc3cncc(c3)C#N)c(CNC(C)(CO)CO)cc2Cl)c1C

InChI Key: InChIKey=SQKMSYMXUDWIGU-DJUQAAIZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 477028   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Programmed cell death 1 ligand/protein 1


(Homo sapiens-Homo sapiens (Human))		BDBM477028
PNG
(US10882844, Example 2006)
Show SMILES C[C@@H]1C[C@H](N)CN1c1nc2cc(ccc2o1)-c1cccc(COc2cc(OCc3cncc(c3)C#N)c(CNC(C)(CO)CO)cc2Cl)c1C |r|
Show InChI InChI=1S/C38H41ClN6O5/c1-23-9-30(41)18-45(23)37-44-33-12-27(7-8-34(33)50-37)31-6-4-5-28(24(31)2)20-49-36-13-35(48-19-26-10-25(14-40)15-42-16-26)29(11-32(36)39)17-43-38(3,21-46)22-47/h4-8,10-13,15-16,23,30,43,46-47H,9,17-22,41H2,1-3H3/t23-,30+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.590n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...

US Patent US10882844 (2021)

More data for this
Ligand-Target Pair