BDBM477670 N-(4-(chlorodifluoromethoxy)phenyl)-2-(2-hydroxyethyl)-1-methyl-7-(pyrimidin-5-yl)-1H-benzo[d]imidazole-5-carboxamide::US10889571, Example 12

SMILES: CNc1c(Br)cc(cc1NC(=O)CC(=O)OC)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key: InChIKey=ZTRMYUUAKIMBTJ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 477670   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human))	BDBM477670 (N-(4-(chlorodifluoromethoxy)phenyl)-2-(2-hydroxyet...) Show SMILES CNc1c(Br)cc(cc1NC(=O)CC(=O)OC)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 Show InChI InChI=1S/C19H17BrClF2N3O5/c1-24-17-13(20)7-10(8-14(17)26-15(27)9-16(28)30-2)18(29)25-11-3-5-12(6-4-11)31-19(21,22)23/h3-8,24H,9H2,1-2H3,(H,25,29)(H,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Terns, Inc. US Patent					Assay Description ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...				US Patent US10889571 (2021)
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