null

SMILES: Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1

InChI Key: InChIKey=HNNCTUYLUZSTEJ-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478981   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 12 (Homo sapiens)	BDBM478981 ((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1 |r| Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
KINNATE BIOPHARMA INC. US Patent					Assay Description For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...				US Patent US10894788 (2021) BindingDB Entry DOI: 10.7270/Q2FB561X
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478981 ((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1 |r| Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478981 ((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1 |r| Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 12 (Homo sapiens)	BDBM478981 ((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1 |r| Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
KINNATE BIOPHARMA INC. US Patent					Assay Description For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...				US Patent US10894788 (2021) BindingDB Entry DOI: 10.7270/Q2FB561X
					More data for this Ligand-Target Pair