null

SMILES: COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl

InChI Key: InChIKey=CIYMVEZDWWJLLN-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 479014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 12 (Homo sapiens)	BDBM479014 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
KINNATE BIOPHARMA INC. US Patent					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				US Patent US10894788 (2021)
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	US11390618, Example 54 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	US11390618, Example 54 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 12 (Homo sapiens)	BDBM479014 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
KINNATE BIOPHARMA INC. US Patent					Assay Description For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...				US Patent US10894788 (2021)
					More data for this Ligand-Target Pair