BDBM48045 3-amino-N-(2-fluorobenzyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::3-amino-N-[(2-fluorophenyl)methyl]-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide::3-amino-N-[(2-fluorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide::3-azanyl-N-[(2-fluorophenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide::VU0402471-1::cid_44176127
SMILES: Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccccc1F
InChI Key: InChIKey=CGFVUNKRJXACED-UHFFFAOYSA-N
Data: 3 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M4 (RAT) | BDBM48045 (3-amino-N-(2-fluorobenzyl)-4,6-dimethyl-thieno[2,3...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 0.000873 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of a Highly Selective in vitro and in vivo... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2251GKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human)) | BDBM48045 (3-amino-N-(2-fluorobenzyl)-4,6-dimethyl-thieno[2,3...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Monash University Curated by ChEMBL | Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO Flp-In cells assessed as stimulation of acetylcholine-induced ERK1/2 ... | J Med Chem 56: 8196-200 (2013) Article DOI: 10.1021/jm401032k BindingDB Entry DOI: 10.7270/Q2HT2S8D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M4 (Homo sapiens (Human)) | BDBM48045 (3-amino-N-(2-fluorobenzyl)-4,6-dimethyl-thieno[2,3...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 126 | n/a | n/a | n/a | n/a |
Monash University Curated by ChEMBL | Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO Flp-In cells assessed as stimulation of acetylcholine-induced ERK1/2 ... | J Med Chem 56: 8196-200 (2013) Article DOI: 10.1021/jm401032k BindingDB Entry DOI: 10.7270/Q2HT2S8D | |||||||||||
More data for this Ligand-Target Pair |