BDBM480529 3-Cyclopropyl-5,7-dimethyl-1-(3-(2-methylthiazol-5-yl)isoquinolin-8-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one::US10899769, Example 13

SMILES: CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1

InChI Key: InChIKey=HSOYPKXYVCVZOK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM480529 (3-Cyclopropyl-5,7-dimethyl-1-(3-(2-methylthiazol-5...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI InChI=1S/C24H23N5OS/c1-13-24(30)28(3)12-20-22(27-23(29(13)20)15-7-8-15)17-6-4-5-16-9-19(26-10-18(16)17)21-11-25-14(2)31-21/h4-6,9-11,13,15H,7-8,12H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021)
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480529 (3-Cyclopropyl-5,7-dimethyl-1-(3-(2-methylthiazol-5...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI InChI=1S/C24H23N5OS/c1-13-24(30)28(3)12-20-22(27-23(29(13)20)15-7-8-15)17-6-4-5-16-9-19(26-10-18(16)17)21-11-25-14(2)31-21/h4-6,9-11,13,15H,7-8,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021)
					More data for this Ligand-Target Pair