BDBM480576 3-cyclopropyl-1- (3-(1,5- dimethyl-1H-pyrazol-4- yl)isoquinolin-8-yl)-5,7- dimethyl-7,8- dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 59

SMILES: CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3C)c(cc12)C#N

InChI Key: InChIKey=VBRWZRVQWASOOS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM480576 (3-cyclopropyl-1- (3-(1,5- dimethyl-1H-pyrazol-4- y...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3C)c(cc12)C#N Show InChI InChI=1S/C26H25N7O/c1-14-20(12-28-32(14)4)23-17(11-27)10-19-18(6-5-7-21(19)29-23)24-22-13-31(3)26(34)15(2)33(22)25(30-24)16-8-9-16/h5-7,10,12,15-16H,8-9,13H2,1-4H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	496	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021)
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480576 (3-cyclopropyl-1- (3-(1,5- dimethyl-1H-pyrazol-4- y...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CC3)n12)-c1cccc2nc(-c3cnn(C)c3C)c(cc12)C#N Show InChI InChI=1S/C26H25N7O/c1-14-20(12-28-32(14)4)23-17(11-27)10-19-18(6-5-7-21(19)29-23)24-22-13-31(3)26(34)15(2)33(22)25(30-24)16-8-9-16/h5-7,10,12,15-16H,8-9,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021)
					More data for this Ligand-Target Pair