null

SMILES: CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1

InChI Key: InChIKey=UMQADUCCACBHKD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 480609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480609 (1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquino...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| Show InChI InChI=1S/C26H27FN6O2/c1-15-26(34)31(2)14-22-24(29-25(33(15)22)16-7-10-35-11-8-16)23-18-13-28-21(20-6-9-32(3)30-20)12-17(18)4-5-19(23)27/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM480609 (1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquino...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| Show InChI InChI=1S/C26H27FN6O2/c1-15-26(34)31(2)14-22-24(29-25(33(15)22)16-7-10-35-11-8-16)23-18-13-28-21(20-6-9-32(3)30-20)12-17(18)4-5-19(23)27/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	879	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170] (Homo sapiens (Human))	BDBM480609 (1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquino...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| Show InChI InChI=1S/C26H27FN6O2/c1-15-26(34)31(2)14-22-24(29-25(33(15)22)16-7-10-35-11-8-16)23-18-13-28-21(20-6-9-32(3)30-20)12-17(18)4-5-19(23)27/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM480609 (1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquino...) Show SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1 |(1.37,5.11,;.9,3.65,;-.61,3.33,;-1.64,4.47,;-1.09,1.86,;-2.57,1.46,;-.05,.72,;1.45,1.04,;2.7,.13,;3.94,1.04,;3.47,2.5,;4.24,3.84,;5.78,3.84,;6.55,5.17,;5.78,6.5,;4.24,6.5,;3.47,5.17,;1.93,2.5,;2.7,-1.41,;4.03,-2.18,;5.36,-1.41,;4.03,-3.72,;2.7,-4.49,;1.36,-3.72,;.03,-4.49,;-1.3,-3.72,;-1.3,-2.18,;.03,-1.41,;1.36,-2.18,;-2.64,-4.49,;-2.64,-6.03,;-4.1,-6.5,;-5.01,-5.26,;-6.55,-5.26,;-4.1,-4.01,)| Show InChI InChI=1S/C26H27FN6O2/c1-15-26(34)31(2)14-22-24(29-25(33(15)22)16-7-10-35-11-8-16)23-18-13-28-21(20-6-9-32(3)30-20)12-17(18)4-5-19(23)27/h4-6,9,12-13,15-16H,7-8,10-11,14H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...				US Patent US10899769 (2021) BindingDB Entry DOI: 10.7270/Q2H41VJJ
					More data for this Ligand-Target Pair